Endocrine Abstracts

We have previously shown that the PGC-1 transcriptional coactivators are major regulators of several crucial aspects of energy metabolism. PGC-1alpha controls many aspects of oxidative metabolism, including mitochondrial biogenesis and respiration through the coactivation of many nuclear receptors, and factors outside the nuclear receptor family. ERRalpha NRF-1 and NRF-2 are key targets of the PGC-1s in mitochodrial biogenesis. We have recently addressed the question of the ro...